en Research Paper Research Paper Single crystals of double crystalline block copolymers of poly(ethylene glycol) (PEG)-<em>b</em>-poly(&epsilon;-caprolactone) (PCL) and PEG-<em>b</em>-poly(L-lactide) (PLLA) were grown from dilute solution in homo- and mixed-brush systems. Crystallization behavior of biodegradable one end-restricted crystallizable PCL and PLLA chains in homo- and mixed-brush nanostructures were investigated. Chemical and physical circumstances of crystallizable brushes were altered. Physical environment was adjusted by amorphism/crystallinity and rigidity/flexibility of neighboring brushes. Chemical environment was manipulated by interaction and miscibility of various brushes. Distinct single crystals were grown with mixed-brushes of amorphous-crystalline (polystyrene (PS), poly(methyl methacrylate) (PMMA), PCL and PLLA, double crystalline (PCL/PLLA), and rod-crystalline polyaniline (PANI)/PCL or PLLA. Surrounding was only effective on hindrance or nucleation commencement of crystallization for crystallizable brushes and had no effect on crystallization features. Novel three-layer fully single crystalline nanostructures, whose characteristics were fixed via changing the crystallization temperature, were also developed. For long crystallizable tethers, crystallization increased both brush and substrate thicknesses.&nbsp; Restricted crystallizable chain,double crystalline block copolymer,single crystal. 1 23 http://ijmse.iust.ac.ir/browse.php?a_code=A-10-2344-5&slc_lang=en&sid=1 Saleheh Abbaspoor s.abbapoor55@yahoo.com 1800319475328460014835 1800319475328460014835 No Mechanical Engineering Department, Faculty of Engineering, Damghan University, Damghan, Iran Farhang Abbasi fa.abbasi2@yahoo.com 1800319475328460014836 1800319475328460014836 No Sahand University Samira Agbolaghi s.agbolaghi@azaruniv.ac.ir 1800319475328460014837 1800319475328460014837 Yes Specifications of Biodegradable Restricted PCL and PLLA Chains in Biocompatible PEG-b-PCL and PEG-b-PLLA Single Crystals