en گروه بایومواد Biomaterials Research Paper Research Paper <span style="font-size:10pt"><span style="line-height:200%"><span linotype="" palatino="" style="font-family:"><span style="color:black"><span style="font-size:11.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">In recent years, Mg- based alloys have been considered as a biodegradable biomaterial for implant applications. However, the high corrosion rate and hydrogen gas evolution in an aqueous environment are the most important challenges for these alloys. This study has focused on optimizing the biocorrosion properties of &nbsp;bioalloys in Mg-Zn-Ca system, using a combined approach of thermodynamic simulations, and response surface methodology (RSM). In, Mg₂Ca and Ca_xMg_yZn_z precipitates have a significant effect on corrosion mechanisms. It is believed that, in the Mg-Zn-Ca alloy system, the Mg₂Ca secondary phase usually enhances corrosion rate with microgalvanic coupling mechanisms. The ternary phases Ca_xMg_yZn_z have less detrimental effects on corrosion resistance. To minimize harmful phases, CompuTherm&rsquo;s PANDAT software was utilized for phase evolution prediction, with outputs directly validated against experimental measurements. Potentiodynamic tafel polarization experiments and long-term immersion tests were conducted to evaluate the corrosion rate. In order to design an alloy with the least detrimental phase, a statistical model (RSM) was developed based on predicted results from thermodynamic model. The results showed that the ZX31 (Mg-2.6Zn-1Ca) exhibited the highest corrosion potential (-1.6336 V_Ag/AgCl) and the lowest corrosion current density (216 &micro;A/cm²), showing higher biocorrosion resistance compared to ZX24 (Mg-2.3Zn-4.0Ca) and ZX15 (Mg-1.3Zn-4.8Ca). </span></span></span></span></span></span></span><br> &nbsp; Magnesium bioalloy,Orthopedic implants,Biocorrosion,Corrosion optimization,Response surface methodology (RSM). 0 0 http://ijmse.iust.ac.ir/browse.php?a_code=A-10-13-13&slc_lang=en&sid=1 M. Reza Aboutalebi mrezab@iust.ac.ir 1800319475328460022560 1800319475328460022560 Yes School of Materials and Metallurgical Engineering, Iran University of Science and Technology (IUST), Narmak, Tehran, Iran